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KMID : 0388420020120010075
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Konkuk Journal of Medical Sciences
2002 Volume.12 No. 1 p.75 ~ p.83
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The Suppressive Effect of L. lactis CBT-8 on Helicobacter pylori Infection
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Jin Chun-Jo
Park Hyung-Seok
Lee Hae-Woon
Kim Sung-Ryel
Kang Dong-Gu
Lee Joon-Sang
Lee Jae-Dong
Wang Joon-Ho
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Abstract
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Helicobacter pylori infection was the cause of chronic gastritis, duodenal ulcer and gastric MALT lymphoma. The eradication rates of H. pylori using antibiotics are around 80%. Lactobacilli have been demonstrated to have in vivo and in vitro inhibitory effects on H. pylori infection. .We aimed to evaluate the inhibitory effect of L. lactis CBT-8 and its extract on H. pylori in human stomach. Thirty-five H. pylori-infected volunteers (30-49 yr)were randomized into tvLo groups which were treated with L. lactis CBT-8 and its extract(Group A n=17) or milk containing L. lactis CBT-8(Group B, n=18). They underwent 13C-urea breath tests before and after treatment. The DOB30 of group A(n=14) was decreased 41.0% after treatment(26.0 4.9 before, 15.32.1 after trea tment)(p<0.05). The DOB30 of group B(n=13) was decreased 22.3% after tr eatment(22.02.2 before, 17.11.7 after treatment) (p<0.05). In conclusion, L. lactis CBT-8 was effective in suppressing H. pylori infection in human stomach.
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KEYWORD
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L. lactis CBT-8, Helicobacter pylori
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